SR. RES. INVESTIGATOR /PRINCIPAL INVESTIGATOR
Syngene International
- Bangalore, Karnataka
- Permanent
- Full-time
- Conduct preclinical/laboratory experiments on late stage BMS portfolio compounds to support annual goals and objectives for Translational Medicine (for internal /external, collaborations, compound specific plans etc).
- Responsible for delivering data in support of translational strategies including biomarkers, patient selection hypotheses, dose and schedule, combination strategies, resistance mechanisms and differentiation. • Report directly to the head of the laboratory and manage laboratory scientists to integrate clinical questions into lab-based translational research internally and externally.
- Interfaces with TM scientists to ensure seamless flow of information for assets which are entering the remit of translational medicine.
- Manages and supervises a portfolio of preclinical collaborations on specific pipeline compounds or clinical assets.
- Assists in managing key strategic and/or collaborative projects along with TM scientists.
- Communicates regularly and prepares and makes presentations within the department, externally and to senior management as required.
- Reports experimental finding in written nonclinical pharmacology study reports, to support regulatory filings.
- Assists in setup and maintenance of group budget and personnel plan
- PhD with relevant work experience across immunology, oncology, heme-oncology focus areas including drug development in an industry setting, especially hematology indications is a plus.
- Strong publication record and track record in large and/or small companies, leading innovative efforts within the laboratory setting to achieve defined goals and support clinical development
- Excellent communication, managerial and scientific qualities are expected • Ability to interact effectively across boundaries using influencing and relationship building skills.
- Competence in analysis and solving of problems, and the ability to prioritize and make tradeoffs to achieve goals.
- Understanding of relevant disease biology, clinical landscape, evolving technologies, competitive scenario
- Cell culture, primary cell isolation, cell transfection
- Proficiency in gene expression methods including qRT-PCR and/or familiarity with RNA sequencing, epigenomic methods including ATAC-seq ChiP-seq,
- Protein analyses and immunoassays, and cell phenotyping analysis
- Familiarity with design, setup and execution of autoimmune, solid tumor oncology or heme-oncology in vivo pharmacology models is a plus.
- Obtain relevant information from published literature, both internal and external. Apply information gathered to solve complex scientific questions and help study data interpretation.
- Maintain a good understanding of the methodological basis and biological significance of assays performed.
- Forecast potential issues regarding support of assays for current and long term projects.
- Devise strategic solutions to identified and potential hurdles/issues; efficiently and proactively troubleshoot technical and experimental problems.
- Strong commitment towards work and a high level of dedication, enthusiasm, and motivation.
- Good speaking-listening-writing skills, attention to detail, proactive self-starter.